Can NMN Supplements Enhance Lifespan? A Look at the Science

As the human lifespan continues to increase worldwide, so is the number of people seeking solutions for age-related conditions. One such solution that has been gaining attention is Nicotinamide Mononucleotide (NMN), a precursor of Nicotinamide Adenine Dinucleotide (NAD+), an essential enzyme for various critical cell functions, including metabolism, DNA repair, cell growth, and survival.Get more news about longevity nmn,you can vist our website!

Recent research into NMN and ageing has shown promising results in cell and animal studies, as well as in clinical trials, fuelling a multimillion-dollar market for NMN supplements. In rodents, NMN has been found to ameliorate the detrimental effects of NAD+ reduction with age, significantly improving several metabolic functions. This has led to NMN being sold worldwide as a dietary supplement.

However, it’s important to note that while the results from animal studies are impressive, there is very little data to support that NMN has beneficial effects in humans. The global NMN market was valued at US$253 million in 2020 and is projected to reach US$386 million by the end of 2027. But what evidence is there that NMN has anti-ageing effects in humans?

NAD+ is found in abundance in mitochondria, the cell cytoplasm, and nucleus. It is required for the addition of poly-ADP ribose to proteins and the deacetylating activity of sirtuin enzymes, which are critical for regulating cell growth, energy metabolism, stress resistance, inflammation, circadian rhythm, and neuronal function. NAD+ is synthesized from sources that include NMN, tryptophan, nicotinic acid, nicotinamide riboside, and nicotinamide.

NAD+ precursors are found in small amounts in natural foods, such as cow’s milk, vegetables, and meats. These precursors enter cells by different means: NMN is probably transported across cell membranes by the Slc12a8 transporter, nicotinamide riboside enters cells via nicotinamide riboside transporters, and nicotinamide diffuses into cells due to its small size. The uptake of NAD+ precursors varies between tissues, but a decline in NAD+ with age is observed across multiple tissues.

Long-term oral administration of NMN has been found to suppress age-associated weight gain, enhance energy metabolism, improve insulin sensitivity, and prevent age-linked changes in gene expression. However, we will need clinical trials before we can state definitively if NMN can extend lifespan in humans.

In conclusion, while NMN shows promise in enhancing lifespan and alleviating age-related conditions, more research is needed to fully understand its effects in humans. As the science continues to evolve, it’s important for individuals to consult with healthcare professionals before starting any new supplement regimen.